The Natarajan laboratory We are interested in the fundamental process of cell fate specification during mammalian development and differentiation at single-cell level. The group aims to understand general paradigms of cell state and fate specification, with a particular interest in transcriptional and epigenetic regulatory networks, and their crosstalk with cell cycle, metabolism and fundamental cellular processes.
We have a interdisciplinary foundation and combine wet-lab experiments with theoretical models and computational approaches at single-cell and bulk level to uncover principles governing cell fate decisions, and their consequences in development and disease. We leverage different developmental (ESCs/hiPSCs), differentiation (CNS, immune) models alongside molecular, cellular and computational approaches.
We study transcriptional and epigenetic crosstalk during iPSC differentiation to CNS cell types (microglia, neurons) via single-cell omics profiling and computational biology.
We develop and apply causal gene regulatory network inference to study factors, interactions, pathways driving cell-state and fate-specification from multi-modal single-cell datasets
We have a strong interest in development, extension and utilisation of new experimental and computational methods for single-cell biology.
Working closely with collaborators, we develop new computational tools that integrate measurements from several single-cell technologies.
Group Leader
Postdoctoral Fellow
Postdoctoral Fellow
PhD Student
PhD Student
Research Assistant
Masters thesis student
Shared lab technician
Our research is possible due to generous support form:
Kedar Natarajan is Associate Professor at DTU Bioengineering at Technical University, Denmark.
The group (Transcriptional regulation and Single-cell systems genomics) is a part of DTU Bioengineering
at Technical University of Denmark.
Transcriptional regulation and Single-cell systems genomics,
DTU Bioengineering
Technical University of Denmark
Søltofts Plads, DK-2800 Kgs. Lyngby
kenana@dtu.dk